The Epanomi region has been continuously inhabited for nearly 6,000 years. Wine-making is attested here for around 1,500 years. In Byzantine times, Era Epanomi was referred to as being a well-known vine-growing region. However, a settlement named "Panomi" was first recorded in a census carried out in 1302.

During the Ottoman Occupation, Panomi was a free, self-governing "kefalochori" (head village), while according to the Ottoman tax records, viticulture and wine-production still continued to flourish in the region.

Epanomi is located 25 km south-east of Thessaloniki within the administrative borders of the Municipality of Thermaikos and the Prefecture of Thessaloniki, forming one of the city's coastal suburbs.

Epanomi is a beautiful rural village of almost 9,000 permanent inhabitants. It is surrounded by sea, and an abundance of different crops, hills covered in olive trees and rich vineyards form a unique landscape. Viticulture has a long tradition in the region, since Epanomi was part of the wider region of "Kalamaria", namely Kali Meria (nice place), a name given by French travelers to denote the high quality of the region's agricultural products.

Local attractions include the churches of Agios Georgios (built in 1835) and the Assumption of the Virgin Mary (built in 1865), the vaulted tombs, the monastery property of Kritsianoi and the lighthouse on Cape Epanomi. Archaeological excavations have revealed many Early Christian-Byzantine finds.

Epanomi is an area of major ecological importance. A uniquely beautiful wetlands of 550 hectares is located in the Fanari area, which hosts rare species of flora and fauna and serves as a haven of migratory and other birds. The Epanomi wetlands has been included in the European Union's program "Natura 2000".

It is worth noting that Epanomi's coastline extends over a length of 40 km. Its crystalline beaches attract many summer visitors and its small taverns, where tourists can enjoy fresh fish, the Greek and local cuisine, good wine, local tsipouro and the warm hospitality of their owners make it an ideal tourist destination.